| Name | dinitrogen tetraoxide |
| Synonyms | dinitrogen tetraoxide nitrogen tetroxide nitrogen dioxide dimer |
| CAS | 10544-72-6 |
| EINECS | 233-272-6 |
| Molecular Formula | N2O4 |
| Molar Mass | 92.01 |
| Density | 1.45 kg/cm³ |
| Melting Point | -11 ℃ |
| Boling Point | 21 ℃ |
| Water Solubility | 可溶 |
| Use | Yellow-brown liquid or gas with pungent odor |
Abstract:
objective to study the effect of anisodamine combined with dexamethasone on the blood gas of experimental animals by replicating the model of N2O4 blast-induced combined injury. Methods 224 healthy male Wistar rats were randomly divided into three groups: ① model Group: Blast injury combined with N2O4 exposure; ② anisodamine group: immediately after injury, 15 min after injury, anisodamine 3 mg/kg was injected intraperitoneally for 3 times 2 h after injury. ③ dexamethasone group: dexamethasone 10 mg/kg was injected intraperitoneally immediately, 15 min,2 h after injury, A total of 3 times. ④Anisodamine combined with dexamethasone group: anisodamine 3 mg/kg and dexamethasone 10 mg/kg were injected three times after injury. Results in the model Group, blood oxygen partial pressure decreased significantly, carbon dioxide partial pressure increased, hemoglobin oxygenation decreased, tissue oxygen supply decreased, and blood acidification was obvious. Early intraperitoneal injection of anisodamine or dexamethasone has certain inhibitory effect on blood gas changes in animals with nitrogen tetroxide combined injury. The combination of the two has a significant reversal effect on blood gas changes. Conclusion the combined application of anisodamine and dexamethasone is effective in the treatment of nitrogen tetroxide poisoning combined injury.
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Key words:
dinitrogen tetroxide; Blast injury; Gas poisoning; blood gas analysis; Anisodamine; Dexamethasone
DOI:
10.3760/cma.j.issn.1007-6239.2001.01.010
cited:
year:
2001
Yue Mao Xing , Heming Yang , Zhang Jianzhong , Li Jianzhong , Wang Zhengguo , Yang Zhihuan , charadong , German Wang , Peng Ruiyun
Abstract:
objective: to replicate the model of dinitrogen tetroxide (N2O4) blast-induced combined injury and to study its effects on hemodynamics and pathomorphology. Methods: 20 healthy adult male Standard Grade One rabbits, weighing 2.74±0.59. They were randomly divided into: ① blast injury group (B);② N2O4 inhalation poisoning group (N);③ poisoning combined injury group (BN). Replication of the toxic compound injury model continuous monitoring of hemodynamic indicators and before and after the control ratio and the same phase between the group ratio. Results: In the early stage after blast injury, the heart rate increased significantly, the mean arterial pressure (MAP), left ventricular systolic pressure (LVSP), ventricular pressure increased maximally, and the rate of decline ± dp/dt max all increased transiently. However, the heart rate, MAP,LVSP,dp/dt max of the animals in the early stage of the nitrogen tetroxide and toxic combined injury group showed a gradual downward trend, and the lowest was 3h-6h after injury. The main pathomorphological changes were: ① the pulmonary blast injury was marked by hemorrhage, the N2O4 poisoning group was slightly mild, more prominent by pulmonary edema, the combined injury group was aggravated by pulmonary hemorrhage and edema; ② myocardial fiber rupture; ③ turbid swelling of liver, with focal and bridging necrosis of liver cells; ④ turbid swelling of kidney, with necrosis of renal tubules; ④ brain: some nerve cells/small-cell ducts and lymphangitic cell voids widened, meningeal vessel dilation and filling. Conclusion: The hemodynamics of rabbits in dinitrogen tetroxide and toxic combined injury group were significantly deteriorated within 3h-6h, and the malignant degree of hemodynamic state of rabbits in toxic combined injury group was more obvious. In addition, the main pathological morphology of the three groups of rabbits were changed, and the damage of the combined injury Group was the most serious, suggesting the importance of early treatment (within 3h-6h) of the combined injury.
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Key words:
dinitrogen tetroxide combined trauma monitoring hemodynamic change pathomorphology
DOI:
10.3760/j.issn:1671-0282.2001.02.012
cited:
year:
2001
Li Shengliang , Wu Zhihong , Zhang Shuqin , Qin Cuiping , Pump , li jia , Ma Sufeng , Chen Zhengtang , Liu Qingfang
Abstract:
clinical data this group of 30 cases of young male patients, aged 19-58 years old, an average of 32.4 years old, due to inhalation leakage of nitrogen tetroxide (N2O4) gas 30-50 min after emergency admission. Clinical manifestations: all patients had chest tightness, palpitations, shortness of breath, dizziness, Nausea, Rhinorrhea, sore throat, irritation Cough, Dyspnea; Cough brown sputum in 14 cases; Dysphoria, 1 case of disturbance of consciousness. Physical examination: Blood Pressure 80-160/50-90 mmHg; Body temperature> 37.2 ℃ in 21 cases, including temperature> 38 ℃ in 10 cases; Fast breathing shallow
Key words:
dinitrogen tetroxide First Aid for poisoning Population male patient Dyspnea irritation Cough Clinical Data emergency admission
DOI:
10.3969/j.issn.1009-6663.2011.02.090
cited:
year:
2011
Yue Mao Xing , Peng , Wang Zhengguo , German Wang , Yang Zhihuan , Heming Yang
Abstract:
Objective to investigate the characteristics and long-term effects of propellant nitrogen tetroxide (N2O4) poisoning in spacecraft. Methods 128 male Wistar rats were randomly divided into 4 groups: 1) blank control group (56 rats);2) Acute Exposure group (56 rats);3) long-term effect control group (8);4) long-term effect Group (8). Acute exposure group was divided into before exposure, after exposure to 3, 6, 12, 24, 48, 72 h and other 7 phases, each group of 8, with the normal value before injury as the basic value, the acute effect of N2O4 exposure was observed by comparison before and after comparison and comparison of the same phase group; the long-term effect control group and the long-term effect group were fed for 1 year, and then the pathological morphology of the main organs were examined (gross, light microscope and electron microscope) to observe the long-term effect. N2O4 was exposed to the concentration of 81 mg/m3 for 15 min. Meanwhile, the long-term effects of N2O4 on rats were observed. Results pulmonary edema was the main pathological manifestation of acute N2O4 exposure: arterial oxygen partial pressure (PaO2) decreased to the lowest (4.58±0.41)kPa 3 h after exposure. In the long-term effect Group, 75% of the rats had pulmonary fibrosis, and some rats had lung adenocarcinoma. Conclusion This study confirms that 2~6 h after acute exposure to N2O4 is the most severe period, the long-term effect is obvious, and pulmonary fibrosis occurs. Prompt treatment of such wounded must be rapid, timely, early treatment at the same time should consider the possible long-term effects of both and treatment, under possible conditions to prevent.stowed
Key words:
propellant N2O4 poisoning long-term effect tumor fibrosis
DOI:
CNKI:SUN:HYXB.0.2004-02-009
cited:
year:
2004